Project title:
Nencki-EMBL Center of Excellence for Neural Plasticity and Brain Disorders: BRAINCITY
Project is carried out within the MAB/IRA programme of the Foundation for Polish Science
Project description:
To study aberrant synaptic plasticity that underlies diseased mind Kaczmarek lab investigates molecular mechanism underlying synaptic plasticity in healthy and diseased mind and has recently demonstrated that matrix metalloproteinase 9 (MMP-9, an extracellularly operating protease previously shown to control molecular, structural and functional synaptic plasticity) plays a pivotal role in alcohol addiction, supporting motivation towards alcohol seeking (Stefaniuk et al., Biological Psychiatry, 2017), as well as contributes to delusional symptoms in schizophrenia (Lepeta et al., EMBO Molecular Medicine, 2017). Knapska lab research is focused on investigation of neural representations of emotional states in interacting animals and humans. Using behavioral models of socially transferred positive and negative emotions as well as high-throughput behavioral measures of social interactions of their own design (Eco-HAB system, Puscian et al., eLife, 2016), neuronal tracing and optogenetic,s as well as brain imaging, they characterize neuronal circuits and cellular mechanisms underlying social interactions of humans rats and mice and validate tissue-specific therapeutic interventions using mouse models of synaptopathies relevant to autism spectrum disorders (Meyza et al., Neurosci Biobehav Rev., 2017).
Key responsibilities include:
Planning and conducting experimental work
Data analysis
Manuscript preparation
Project leaders: Leszek Kaczmarek and Ewelina Knapska
Profile of candidates/requirements:
Strong interest in the brain research, especially in understanding the brain-mind connection
M.Sc. degree, or equivalent, in molecular biology, biochemistry, biotechnology, physics/biophysics, biology, psychology, medical or veterinary sciences
Exceptional motivation for the scientific research (demonstrated via publications, references of the candidate's thesis tutor)
Proficiency in English
Required documents:
Cover letter
Copies of diplomas
Copies of documents confirming the course of studies
Curriculum vitae including a description of scientific and professional achievements and list of publications
Copies of documents confirming the scientific or professional achievements
Consent to the processing of personal data for the purpose of recruitment
Optionally opinion of a researcher or academic teacher holding at least the academic degree of PhD (doctor) concerning the candidate and his / her scientific activity
Please submit the following documents to:
http://warsaw4phd.eu/register.php
(please apply from June 4th 2019)
Full-time stipend in the top-ranked research institute in Poland 4 500 PLN/month (ca. 1 000 EUR/month)
Access to modern equipment and support from other experienced researchers.
Possibility for extensive interdisciplinary collaborations within the team and in the Institute, as well as international collaborations with Academia
For more details about the position please visit (website/webpage address):
http://neurogene2.nencki.gov.pl
http://knapskalab.eu/index.php/en/
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